Proto-oncogene tyrosine-protein kinase src
Aguirre SA, Heyen JR, Collette W, Bobrowski W, Blasi ER (April 2010).
"A genetic variant that disrupts MET transcription is associated with autism".
This gene is highly similar to the uncompress rar files windows 8 v-src gene of Rous sarcoma virus.
A b "he fields of HGF/c-Met involvement"."Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase".Evidence on tissue expression from tissues for SRC Gene Blood(4.7) Lung(4.6) Liver(4.5) Skin(4.5) Kidney(3.2) Nervous system(3.1) Heart(3) Intestine(2.9) Muscle(2.8) Stomach(2.8) Adrenal gland(2.6) Bone marrow(2.6) Spleen(2.6) Bone(2.4) Pancreas(2.4) Eye(2.3) Lymph node(2.2) Primer Products No data available for mRNA differential expression in normal tissues and Phenotype-based relationships.12 (20 Pt 1 614452.Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2."Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain".Maina F, Casagranda F, Audero E, Simeone A, Comoglio PM, Klein R, Ponzetto C (November 1996).32 40 HGF expression is restricted to cells of mesenchymal origin."Hepatocyte growth factor-induced signal transduction in two normal mouse epithelial cell lines".34 MET is essential for embryogenesis, because MET / mice die in utero due to severe defects in placental development."Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein".Kemp LE, Mulloy B, Gherardi E (2006).Activation of the MET receptor regulates synapse formation and can impact the development and function of circuits involved in social and emotional behavior.113:983-988(2001) PubMed Europe PMC Abstract Cited for: variants TYR-835 DEL; HIS-835 AND TYR-835, involvement IN AML.It is composed of murine variable domains for the heavy and light chains with human IgG1 constant domains.When HGF/SF binds its cognate receptor MET it induces its dimerization through a not yet completely understood mechanism leading to its activation.
The transducers interact with the intracellular multisubstrate docking site of MET either directly, such as GRB2, SHC, 20 SRC, and the p85 regulatory subunit of phosphatidylinositol-3 kinase ( PI3K 20 or indirectly through the scaffolding protein Gab1 Tyr 1356 of the multisubstrate docking site are.Maehama T, Dixon JE (May 1998)."Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor".Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues."Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter"."Regulation of c-Met-dependent gene expression by pten".